methylmercury chloride coaxed oxidative stress in rats

نویسندگان

sh. nabi

a. ara

sh. jahan rizvi

چکیده

the present experiment was designed to access the effects of methylmercury chloride ( mehgcl) on antioxidant status, protein concentration, lipid peroxidation and hydroperoxidation in brain parts, spinal cord, lung, heart and pancreas of rats. twenty male wistar rats (3 months old) were divided in saline controls (c) and mehgcl-treated group (mmc). treated rats were intoxicated with mmc at a dose of 2 mg/kg body weight orally by gavage once a day for 14 consecutive days, for the next 14 days, they were kept intoxicated. control animals received a corresponding volume of isotonic saline. health, total feed intake and body weights of rats were monitored daily throughout the study. both the groups were sacrificed on 29 th day. study revealed an increase in lipid peroxide (lpo) and lipid hydroperoxide (lhpo) levels after mehgcl administration. the levels of superoxide dismutase (sod), catalase (cat), reduced glutathione (gsh), total sulfhydryl (tsh) and protein were significantly declined in all the tissues of mmc treated group as compared to controls. in summary, depletion of antioxidant enzymes in tissues increases mehgcl accumulation and enhances mehg-induced oxidative stress, especially lpo and lhpo which plays an important role in tissue degeneration process during mehgcl intoxication. results support the hypothesis that depletion of antioxidant enzymes is a primary mechanism of organic mercury toxicity. the present experiment was designed to access the effects of methylmercury chloride ( mehgcl) on antioxidant status, protein concentration, lipid peroxidation and hydroperoxidation in brain parts, spinal cord, lung, heart and pancreas of rats. twenty male wistar rats (3 months old) were divided in saline controls (c) and mehgcl-treated group (mmc). treated rats were intoxicated with mmc at a dose of 2 mg/kg body weight orally by gavage once a day for 14 consecutive days, for the next 14 days, they were kept intoxicated. control animals received a corresponding volume of isotonic saline. health, total feed intake and body weights of rats were monitored daily throughout the study. both the groups were sacrificed on 29 th day. study revealed an increase in lipid peroxide (lpo) and lipid hydroperoxide (lhpo) levels after mehgcl administration. the levels of superoxide dismutase (sod), catalase (cat), reduced glutathione (gsh), total sulfhydryl (tsh) and protein were significantly declined in all the tissues of mmc treated group as compared to controls. in summary, depletion of antioxidant enzymes in tissues increases mehgcl accumulation and enhances mehg-induced oxidative stress, especially lpo and lhpo which plays an important role in tissue degeneration process during mehgcl intoxication. results support the hypothesis that depletion of antioxidant enzymes is a primary mechanism of organic mercury toxicity.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Methylmercury Chloride Coaxed Oxidative Stress in Rats

The present experiment was designed to access the effects of Methylmercury chloride ( MeHgCl) on antioxidant status, protein concentration, lipid peroxidation and hydroperoxidation in brain parts, spinal cord, lung, heart and pancreas of rats. Twenty male Wistar rats (3 months old) were divided in saline controls (C) and MeHgCl-treated group (MMC). Treated rats were intoxicated with MMC ...

متن کامل

Methylmercury Chloride Coaxed Oxidative Stress in Rats

The present experiment was designed to access the effects of Methylmercury chloride (MeHgCl) on antioxidant status, protein concentration, lipid peroxidation and hydroperoxidation in brain parts, spinal cord, lung, heart and pancreas of rats. Twenty male Wistar rats (3 months old) were divided in saline controls (C) and MeHgCl-treated group (MMC). Treated rats were intoxicated with MMC at a dos...

متن کامل

Oxidative Stress Response in Rats

Résumé The purpose of this study was to determine if changes in oxidative stress biomarkers in blood and skeletal muscles are similar in normal and antioxidant supplemented rats after a downhill run. Sixty-six male Sprague-Dawley rats were pretreated with a normal rat diet or diet + antioxidants (2,000 mg vitamin C + 1,000 IU vitamin E/kg diet) for 2 weeks. Exercised rats ran 90 min on a rodent...

متن کامل

Alagebrium chloride protects the heart against oxidative stress in aging rats.

To investigate the possible effects of alagebrium chloride (ALT-711) on oxidative stress (OS) process in aging hearts, we examined the role of ALT-711 in cardiac function and OS in the heart of aging rats. Increased mitochondrial DNA (mtDNA) deletion as well as nearly a twofold increase in advanced glycation end products (AGEs) accumulation were observed in aging heart, whereas only about 50% o...

متن کامل

Garlic (Allium sativum) juice protects from semen oxidative stress in male rats exposed to chromium chloride

Semen oxidation is one of the major testimonies of infertility. The aim of present study was to examine the effects of fresh garlic juice on semen malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS) compared with chromium chloride (CrCl3) in male rats. A hundred and sixty-two male rats were allocated into 9 treatment groups. Group 1...

متن کامل

Melatonin attenuates acute renal failure and oxidative stress induced by mercuric chloride in rats.

We evaluated the effect of melatonin (Mel), a potent scavenger of reactive oxygen species, in the course of HgCl(2)-induced acute renal failure. Rats received by gastric gavage 1 mg/kg of Mel (n = 21) or vehicle (n = 21), 30 min before the subcutaneous injection of HgCl(2) (2.5 mg/kg). Rats were killed at 24, 48, and 72 h, and plasma creatinine (S(cr)), renal histology, proliferative activity, ...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pharmacology and therapeutics

جلد ۱۰، شماره ۲، صفحات ۵۲-۰

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023